Whats behind the cause of Inflammatory Bowel Disease (IBD)
IBD is chronic inflammatory disorder of the gastrointestinal tract
Specific genetic variations linked to an increased risk of IBD can affect the immune response to gut bacteria, leading to inflammation
In IBD, a dysregulated immune response mistakenly attacks cells of the gastrointestinal tract, sparking inflammation
Diet, smoking, and exposure to certain infections can trigger or exacerbate the inflammatory response in the gut
Alterations in gut microbiota disrupt the balance between the immune system and microbiota, contributing to chronic inflammation
In IBD patients, a compromised intestinal barrier allows bacteria and other antigens to penetrate the intestinal wall, leading to inflammation
Small Intestinal Bacterial Overgrowth (SIBO) characterized by an overgrowth of bacteria in the small intestine, is often associated with IBD
Fibrostenosing disease, a complication of IBD, increases the risk of SIBO, particularly in individuals with Crohn's disease
IBD is caused by a complex interaction of genetic susceptibility, immune response, environmental factors, gut microbiota, intestinal barrier function, and SIBO